Our understanding of CCSVI and the most commonly associated symptoms has evolved since we first began treating patients. Based on a growing body of patient data (see below), we have arrived at the conclusion that patients with CCSVI typically experience symptoms of autonomic dysfunction. The data is so compelling that we now pre-screen patients for the presence of autonomic symptoms.

Abnormal autonomic function associated with CCSVI can be clinically diagnosed based on a common set of symptoms. These symptoms include fatigue, sleep disturbances, altered cognitive function, cold or heat intolerance, headaches, and bladder or bowel dysfunction. Patients diagnosed with CCSVI who experience symptoms of autonomic dysfunction often benefit greatly from the CCSVI procedure.


Fatigue is not the same as being tired. Fatigue doesn’t respond to sleep as tiredness would. Fatigue is a lack of energy. In some cases it is so severe that it results in the inability to move or think. Fatigue is the most common symptom to improve after treatment and can have the biggest impact on a patient’s life. Restoring a patient’s ability to exercise can improve their overall health.

Sleep Disturbances

Interrupted sleep (waking up after sleeping only a few hours) is a common complaint among patients suffering from autonomic dysfunction. Following treatment, the quality and duration of sleep is typically improved. Many patients note dreaming for the first time in years.

Altered Cognitive Function (Brain Fog)

‘Brain fog’ is a common term used to describe issues related to cognition. This may include poor short-term memory, lack of concentration and trouble with word finding. Some describe being in a ‘foggy’ or ‘hazy’ state. This is the second most common symptom to improve following treatment. Restoring cognitive function can have a dramatic effect on a patient’s ability to work, interact socially, and complete tasks that require concentration. Find out more about brain fog treatment.

Thermal Intolerance

The body functions best at normal temperature (37C). The extremities function like radiators. By altering the amount of blood flow to the hands and feet the body can adjust its temperature. This is controlled by the autonomic nervous system, the body’s thermostat. Autonomic dysfunction results in poor thermal regulation. Patients describe ‘melting’ in the heat and becoming ‘stiff’ in cold weather. This is one of the top three symptoms to respond. For patients with severe thermal intolerance (those who must confine themselves to carefully climate controlled environments), a more normal lifestyle is possible directly following treatment.


Headaches that are present when you wake up (waking headaches) are unique from other common and better understood types of headaches and migraines. The fact that they occur during the rest period makes them distinct from migraines or tension headaches, that are not normally known to occur during sleep. Less than a quarter of our patients describe suffering from autonomic headaches. Waking headaches are among the set of symptoms that are highly responsive to treatment.

Bladder or Bowel Dysfunction

Bladder or Bowel Dysfunction is typically described as ‘urgency’, meaning the need to urinate immediately at the first sensation of a full bladder. Frequency, hesitancy, retention or incontinence may also be present. Constipation, rectal urgency or bowel incontinence may occur. Treatment will often result in improved bowel and bladder function. Patients with previous use of indwelling catheters may not see the same response as those not having used such devices.

Stomach pain

Gastrointestinal symptoms such as bloating or early satiety are seen with autonomic dysfunction. If pain is severe we advise that you should seek medical advice. Digestion is regulated in large part by the autonomic system. In some cases treatment helps with symptoms related to impaired digestion.


Inability to achieve or maintain a penile erection. Typically see a response when this is present in younger male patients.


Abnormally increased muscle tone, sometimes painfully so. Involuntary muscle contractions may also occur. Treatment commonly decreases the abnormal muscle tone experienced with dysautonomia. THis is particularly true of the muscles of the shoulders and neck. The squeezing of the chest sensation “MS hug” is also relieved.

POTS (Postural Orthostatic Tachycardia Syndrome)

A dramatic increase in pulse that does not lead to a decline in blood pressure when they attempt to stand (orthostatic hypotension) from a sitting or supine position. Patients experience dizziness, nausea, palpitations, heat, fatigue, and blackouts. See our page on POTS.

Visual Disturbances

Driving at night is more difficult as the pupil doesn’t respond as well as it should. Autonomic control of the pupillary response improves in some patients. Night driving improves as a result.

Altered Sweating

In ability to perspire is linked is a product of autonomic dysfunction in many cases. Alternatively some patients, particularly those with Lyme Disease, there is abnormally increased sweating. This can include night sweats.

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Ongoing Clinical Research

Observations made with early patients led to recognition that response to treatment was strongly associated with the presence of autonomic symptoms. In the spring of 2011 patients were pre-screened for these symptoms prior to acceptance for treatment. This chart demonstrates the relative frequency of autonomic symptoms in approximately 500 patients seen since adoption of the pre-screening program.

Symptom Distribution
Sleep Disturbances
Waking Headaches
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